The dynamics of the total bioelectrical activity and the parameters of its intercentral interaction was investigated in 52 neurosurgical patients with a focal lesion at the level of the brainstem with the aim of analysis of the compensatory neurodynamic reorganizations of the human brain in the early postoperative period. The study was based on the precise verification of the topography of the pathological focus within the limits of the brainstem; on the dynamic clinical-neurological assessment of different variants of the postoperative course; and on a study of the structure of cortical bioelectrical activity based on visual and spectral coherence analysis. The dependance is demonstrated of the compensatory neurodynamic reorganizations of the brain on the character and degree of the stem lesion (transitory, stable, irreversible).