Abstract
Pneumocystis carinii pneumonia in patients with chronic lymphocytic leukaemia (CLL) who have not been treated with fludarabin are rare, although clinically relevant CD4 T-cell depletion can occur in longstanding CLL without prior treatment with purine analogues. A 52 year old woman is reported who was on long term treatment with chlorambucil and taking a short course of prednisone for familial CLL before she developed progressive dyspnoea, and P carinii pneumonia was diagnosed in bronchoalveolar lavage fluid. Despite treatment with high dose co-trimoxazole the patient died.
MeSH terms
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Anti-Infective Agents / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Chlorambucil / administration & dosage
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Dyspnea / etiology
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Fatal Outcome
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Female
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics
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Middle Aged
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Opportunistic Infections / complications*
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Opportunistic Infections / drug therapy
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Pedigree
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Pneumonia, Pneumocystis / complications*
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Pneumonia, Pneumocystis / drug therapy
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Prednisone / administration & dosage
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Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
Substances
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Anti-Infective Agents
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Chlorambucil
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Trimethoprim, Sulfamethoxazole Drug Combination
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Prednisone