Studies were carried out to the find out the efficacy of the ultrasonic irradiation as a pre-treatment step for the treatment of one of the polluting industrial effluents, the distillery spentwash. Experiments were carried out on the fresh and stored effluent samples. The effect of the ultrasound exposure on the biodegradability of the effluent was monitored by carrying out its subsequent aerobic oxidation. A comparison has been made between the efficacies of the pre-treated samples with the untreated samples. The results indicate that the ultrasound seems to increase the attractiveness of the conventional aerobic oxidation process by increasing their initial rates of degradation.