[Inhibition of reproduction of the human immunodeficiency virus in cell culture by 2',3'-dideoxynucleoside-5'-phosphites]

E V Karamov; V V Lukashov; A P Gorbacheva; T V Makarova; G V Kornilaeva; N B Tarusova; A A Kraevskiĭ

[Inhibition of reproduction of the human immunodeficiency virus in cell culture by 2',3'-dideoxynucleoside-5'-phosphites]

Mol Biol (Mosk). 1992 Jan-Feb;26(1):201-7.

[Article in Russian]

Authors

E V Karamov, V V Lukashov, A P Gorbacheva, T V Makarova, G V Kornilaeva, N B Tarusova, A A Kraevskiĭ

PMID: 1508170

Abstract

5'-Phosphites (5'-hydrogenphosphonates) of 2',3'-dideoxynucleosides (T, A, G, C) were synthesized and studied as inhibitors of human immunodeficiency virus type 1 (HIV-1) in MT4 and CEM13 cell cultures. It was shown that all 5'-phosphites effectively inhibit the production of viral antigens and protect cells from the cytotoxic effect of HIV infection. 5'-Phosphites were more active antiviral compounds than the corresponding nucleosides.

MeSH terms

Antiviral Agents / pharmacology*
Cells, Cultured
Dideoxynucleosides / pharmacology*
Dideoxynucleotides
Enzyme-Linked Immunosorbent Assay
HIV Antigens / analysis
HIV-1 / physiology*
Thymine Nucleotides / pharmacology*
Virus Replication / drug effects*
Zidovudine / analogs & derivatives*
Zidovudine / metabolism
Zidovudine / pharmacology

Substances

Antiviral Agents
Dideoxynucleosides
Dideoxynucleotides
HIV Antigens
Thymine Nucleotides
Zidovudine
zidovudine triphosphate