Vatairea macrocarpa lectin induces paw edema with leukocyte infiltration

Protein Pept Lett. 2004 Apr;11(2):195-200. doi: 10.2174/0929866043478284.

Abstract

A lectin from Vatairea macrocarpa (Vmac) seeds was investigated in a model of paw edema in rats and the possible involvement of leukocytes. Vmac (200 and 400 microg/paw, s.c.) induced a significant time- and dose-dependent paw edema, with leukocyte infiltration, which was drastically reduced in leukopaenic animals. These data suggest a pro-inflammatory effect for this lectin that is dependent on the presence of leukocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Movement / drug effects
  • Edema / chemically induced*
  • Edema / pathology
  • Fabaceae / chemistry*
  • Female
  • Hindlimb / pathology
  • Injections, Subcutaneous
  • Leukocytes / drug effects
  • Leukocytes / pathology
  • Plant Lectins / isolation & purification*
  • Plant Lectins / toxicity
  • Rats
  • Rats, Wistar
  • Seeds / anatomy & histology
  • Seeds / chemistry

Substances

  • Plant Lectins