The prevalence morbidity of AIDS rises day after day. As the first symptom of this disease usually occurs in maxillofacial region,it must be well attentioned to the dentists. Here introducing a case who was a patient of AIDS. He was first see doctor in july 1995 in our Department, associating with foreign documents, the authors described all kinds of clinic symptoms of AIDS on oral and maxillofacial region in early to late stage.The typical one includes hairy leukoplakia,monilia albicans infection of angular stomatitis and mucous membrane,KS,etc.At last,the authors indicated there are some preventive methods to the disease for the dentists.