Curvicollides A-C: new polyketide-derived lactones from a sclerotium-colonizing isolate of Podospora curvicolla (NRRL 25778)

Yongsheng Che; James B Gloer; Donald T Wicklow

doi:10.1021/ol0498186

Curvicollides A-C: new polyketide-derived lactones from a sclerotium-colonizing isolate of Podospora curvicolla (NRRL 25778)

Org Lett. 2004 Apr 15;6(8):1249-52. doi: 10.1021/ol0498186.

Authors

Yongsheng Che¹, James B Gloer, Donald T Wicklow

Affiliation

¹ Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA.

PMID: 15070309
DOI: 10.1021/ol0498186

Abstract

Curvicollides A-C (1-3) have been obtained from cultures of an isolate of Podospora curvicolla (NRRL 25778) that colonized a sclerotium of Aspergillus flavus. The structures of these compounds were elucidated by analysis of one- and two-dimensional NMR data. The lead compound (1) showed antifungal activity against A. flavus and Fusarium verticillioides. [structure: see text]

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Ascomycota
Aspergillus flavus / drug effects
Fusarium / drug effects
Lactones / isolation & purification*
Lactones / pharmacology
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Podospora / chemistry*

Substances

Antifungal Agents
Lactones
curvicollide A
curvicollide B
curvicollide C