Non-compliance is not only an epistemological error but a biological impossibility. This profound statement arises from the influence of Humberto Maturana's revolutionary meta-theory of cognition. The definitions and significant implications of two major theoretical concepts of this meta-theory of cognition, namely structural determinism and objectivity-in-parenthesis, are discussed. These radical concepts challenge the approved North American Nursing Diagnostic Association's nursing diagnosis of non-compliance. Maturana's theory reveals the impossibility of instructive interaction, leading the authors to conclude the non-existence of non-compliant families.