Abstract
Background:
In a case-control study of 100 preeclamptics and 100 controls, we assessed plasma transforming growth factor-beta1 (TGF-beta1) concentrations in relation to preeclampsia risk among Peruvian women with and without systemic inflammation.
Methods:
Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Results:
The OR of preeclampsia increased across quartiles of TGF-beta1 concentrations. Women with elevated TGF-beta1 and a proinflammatory profile experienced the highest risk of preeclampsia (OR = 15.4, 95% CI 4.7-50.4).
Conclusions:
Our results confirm an association between TGF-beta1 and risk of preeclampsia and extend the literature by indicating a strong association in women with systemic inflammation.
Publication types
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Comparative Study
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Evaluation Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Antigens, CD / blood
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Biomarkers / blood
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Case-Control Studies
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Cytokines / blood
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Female
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Humans
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Inflammation Mediators / blood*
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Maternal Age
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Maternal Welfare
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Peru / epidemiology
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Pre-Eclampsia / blood*
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Pre-Eclampsia / epidemiology
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Pregnancy
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Receptors, Tumor Necrosis Factor / blood
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Receptors, Tumor Necrosis Factor, Type I
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Risk Factors
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Statistics as Topic
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Transforming Growth Factor beta / blood*
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Transforming Growth Factor beta1
Substances
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Antigens, CD
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Biomarkers
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Cytokines
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Inflammation Mediators
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Type I
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TGFB1 protein, human
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Transforming Growth Factor beta
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Transforming Growth Factor beta1