Transforming growth factor-beta1 (TGF-beta1) in plasma is associated with preeclampsia risk in Peruvian women with systemic inflammation

Am J Hypertens. 2004 Apr;17(4):334-8. doi: 10.1016/j.amjhyper.2003.12.010.

Abstract

Background: In a case-control study of 100 preeclamptics and 100 controls, we assessed plasma transforming growth factor-beta1 (TGF-beta1) concentrations in relation to preeclampsia risk among Peruvian women with and without systemic inflammation.

Methods: Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).

Results: The OR of preeclampsia increased across quartiles of TGF-beta1 concentrations. Women with elevated TGF-beta1 and a proinflammatory profile experienced the highest risk of preeclampsia (OR = 15.4, 95% CI 4.7-50.4).

Conclusions: Our results confirm an association between TGF-beta1 and risk of preeclampsia and extend the literature by indicating a strong association in women with systemic inflammation.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Antigens, CD / blood
  • Biomarkers / blood
  • Case-Control Studies
  • Cytokines / blood
  • Female
  • Humans
  • Inflammation Mediators / blood*
  • Maternal Age
  • Maternal Welfare
  • Peru / epidemiology
  • Pre-Eclampsia / blood*
  • Pre-Eclampsia / epidemiology
  • Pregnancy
  • Receptors, Tumor Necrosis Factor / blood
  • Receptors, Tumor Necrosis Factor, Type I
  • Risk Factors
  • Statistics as Topic
  • Transforming Growth Factor beta / blood*
  • Transforming Growth Factor beta1

Substances

  • Antigens, CD
  • Biomarkers
  • Cytokines
  • Inflammation Mediators
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Type I
  • TGFB1 protein, human
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1