Abstract
Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients. We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia. The agranulocytosis was rapidly resolved by granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin.
MeSH terms
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Aged
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Agranulocytosis / chemically induced*
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Agranulocytosis / drug therapy
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Anti-Bacterial Agents / adverse effects*
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Anti-Bacterial Agents / therapeutic use
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Catheters, Indwelling / microbiology
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Granulocyte Colony-Stimulating Factor / therapeutic use
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Humans
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Kidney Failure, Chronic / complications
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Kidney Failure, Chronic / therapy
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Male
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Peritoneal Dialysis, Continuous Ambulatory
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Staphylococcal Infections / drug therapy
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Vancomycin / adverse effects*
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Vancomycin / therapeutic use
Substances
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Anti-Bacterial Agents
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Granulocyte Colony-Stimulating Factor
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Vancomycin