Two groups of adolescents with nodular lesions of the thyroid were treated: 17 patients of group 1 received efferent therapy (autohemoozonotherapy by V.I. Afanasyev) and routine pharmacological treatment; 41 controls received drugs only (levothyroxine or potassium iodide). The results were evaluated 6 and 12 months after treatment. The study group patients demonstrated marked improvement of blood flow, structure of thyroid tissue. Growth stabilization and reduction of the thyroid lesion occurred more frequently, complications or side effects were not observed.