RETRACTED: A human chondrogenic cell line retains multi-potency that differentiates into osteoblasts and adipocytes

Bone. 2004 Apr;34(4):648-55. doi: 10.1016/j.bone.2003.12.016.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the author, Dr. Kimihito Yagami. Dr. Yagami's collaborators Yohei Uyama, Yasumasa Yoshizawa, Saburo Kakuta, Akira Yamaguchi, Masao Nagumo were not involved in the RT-PCR experiments and figure preparation The editor, Sundeep Khosla, was notified by an independent group that specific bands in Figure 3 of the paper appear to be duplicated. This was brought to the attention of the authors. Due to the long interval from the original publication of the paper, the raw data was not available; however, the authors subsequently chose to retract the entire manuscript, and the editor agreed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Adipocytes / cytology*
  • Adipocytes / drug effects
  • Alkaline Phosphatase / genetics
  • Alkaline Phosphatase / metabolism
  • Animals
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins / genetics
  • Bone Morphogenetic Proteins / pharmacology
  • Calcium / metabolism
  • Cell Differentiation* / drug effects
  • Cell Line, Tumor
  • Chondrocytes / cytology*
  • Chondrocytes / drug effects
  • Diffusion
  • Humans
  • Mesoderm / cytology
  • Mesoderm / drug effects
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Osteoblasts / cytology*
  • Osteoblasts / drug effects
  • Osteocalcin / genetics
  • Osteocalcin / metabolism
  • Peritoneal Cavity
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Recombinant Proteins
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / pharmacology

Substances

  • BMP2 protein, human
  • Bmp2 protein, mouse
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins
  • RNA, Messenger
  • Recombinant Proteins
  • Transforming Growth Factor beta
  • recombinant human bone morphogenetic protein-2
  • Osteocalcin
  • Alkaline Phosphatase
  • Calcium