Synthesis and evaluation of lasonolide A analogues

Jung Min Joo; Hyo Shin Kwak; Jin Hyun Park; Ho Young Song; Eun Lee

doi:10.1016/j.bmcl.2004.01.088

Synthesis and evaluation of lasonolide A analogues

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1905-8. doi: 10.1016/j.bmcl.2004.01.088.

Authors

Jung Min Joo¹, Hyo Shin Kwak, Jin Hyun Park, Ho Young Song, Eun Lee

Affiliation

¹ School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-747, South Korea.

PMID: 15050624
DOI: 10.1016/j.bmcl.2004.01.088

Abstract

Homolasonolide A and 10-desmethyllasonolide A are biologically less active than lasonolide A. The ethyl ester analogue of lasonolide A exhibited higher activity than the parent compound in some biological test.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Division / drug effects
Cell Line, Tumor
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Macrolides / chemical synthesis*
Macrolides / chemistry
Macrolides / pharmacology*
Stereoisomerism

Substances

10-desmethyllasonolide A
Macrolides
homolasonolide A
lasonolide A