Abstract
The essential components of the immune system that control primary and chronic infection with herpes simplex virus type 1 (HSV-1) in mice were investigated. Infection within the first few days can be controlled by alpha/beta interferon (IFN-alpha/beta) alone without significant contribution of B, T, or NK cells. IFN-alpha/beta and IFN-gamma cooperate in the elimination of virus in the absence of these lymphocytes. In contrast, B, T, or NK cells appear to be required to control persistent infection with HSV-1. These results suggest that distinct and essential immune elements are recruited in a time-dependent fashion to control acute and persistent HSV-1 infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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B-Lymphocytes / immunology
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Central Nervous System Infections / immunology
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Central Nervous System Infections / virology
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DNA, Viral / isolation & purification
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Herpes Simplex / immunology
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Herpes Simplex / virology
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Herpesvirus 1, Human / immunology*
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Herpesvirus 1, Human / isolation & purification
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Herpesvirus 1, Human / pathogenicity
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Interferon gamma Receptor
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Interferons / physiology*
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Killer Cells, Natural / immunology
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Lymphocyte Subsets / immunology*
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Membrane Proteins
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Mice
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Mice, Congenic
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Mice, Inbred C57BL
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Mice, Knockout
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Receptor, Interferon alpha-beta
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Receptors, Interferon / deficiency
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Receptors, Interferon / genetics
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Receptors, Interferon / physiology
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T-Lymphocytes / immunology
Substances
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DNA, Viral
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Membrane Proteins
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Receptors, Interferon
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Receptor, Interferon alpha-beta
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Interferons