Abstract
The molecular characterization of five clinical isolates of vanA-containing vancomycin-resistant enterococci with altered resistance to glycopeptides was examined. One strain represented an IS1216V insertion accompanied by partial deletion of the reading frame of vanX following a transposition event. The other four strains represented IS1216V within the vanX-vanY intergenic region associated with deletion of vanY or vanZ.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics*
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Carbon-Oxygen Ligases / genetics*
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Chromosome Mapping
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Chromosomes, Bacterial / genetics
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Electrophoresis, Gel, Pulsed-Field
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Enterococcus faecium / drug effects*
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Enterococcus faecium / genetics*
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Genes, Bacterial / genetics*
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Genotype
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Glycopeptides / pharmacology*
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Gram-Positive Bacterial Infections / microbiology
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Korea
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Multigene Family / genetics*
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Phenotype
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Reverse Transcriptase Polymerase Chain Reaction
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Vancomycin Resistance / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Glycopeptides
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VanA ligase, Bacteria
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VanB protein, Enterococcus
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Carbon-Oxygen Ligases