Abstract
Four new sterols have been isolated from the marine sponge Axinella cf. bidderi, 17alpha-hydroxy-22,23-epoxy-24-methylcholest-5-en-3beta-ol (1) and 17alpha-hydroxy-22,23-epoxycholest-5-en-3beta-ol (2), together with 3 and 4, which possess respectively the cholestene and the cholestane skeleton with a cyclic enol ether linkage between C-18 and C-22. The structures were elucidated using spectroscopic data. The in vitro activity was evaluated against prostate, ovary, pancreas, colon, and lung cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cholestenes / chemistry
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Cholestenes / isolation & purification*
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Cholestenes / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Indian Ocean
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / chemistry*
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Stereoisomerism
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Tumor Cells, Cultured
Substances
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17alpha-hydroxy-22,23-epoxy-24-methylcholest-5-en-3beta-ol
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17alpha-hydroxy-22,23-epoxycholest-5-en-3beta-ol
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Antineoplastic Agents
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Cholestenes