By nature of their long-term deployment in challenging areas of the world, expatriate employees and their dependents are at increased risk for a number of infectious diseases. Targeted immunization strategies may decrease this risk. Expatriate employees and their dependents should be immunized before deployment, and programs should be established to provide booster immunizations if the risk is ongoing. When considering work-force productivity, work-force infectivity, and the common good, careful consideration should be given to establishing at least a basic immunization program for in-country nationals and their dependents.