Amphidinolides, bioactive macrolides from symbiotic marine dinoflagellates

Abstract

This review covers the structures, synthesis, biosynthesis, and bioactivity of a series of cytotoxic macrolides, named amphidinolides, isolated from symbiotic marine dinoflagellates of the genus Amphidinium which were separated from inside cells of marine flatworms. The structures of long-chain polyketides such as colopsinols isolated from Amphidinium sp. are also described.