The role of aldosterone in heart failure and the clinical benefits of aldosterone blockade

Expert Rev Cardiovasc Ther. 2004 Jan;2(1):29-36. doi: 10.1586/14779072.2.1.29.

Abstract

Aldosterone has a variety of detrimental effects on the heart and vasculature and is increasingly recognized as an important target in chronic heart failure, as illustrated by the Randomized Aldactone Evaluation Study. In this article, the evidence supporting the cardiovascular effects of aldosterone in humans and the proven benefits of aldosterone-receptor antagonists in heart failure shall be discussed.

Publication types

  • Review

MeSH terms

  • Aldosterone / adverse effects
  • Aldosterone / metabolism
  • Aldosterone / physiology*
  • Autonomic Nervous System Diseases / etiology
  • Endomyocardial Fibrosis / etiology
  • Eplerenone
  • Heart Failure / drug therapy*
  • Humans
  • Mineralocorticoid Receptor Antagonists / therapeutic use*
  • Spironolactone / analogs & derivatives*
  • Spironolactone / therapeutic use*
  • Vascular Diseases / etiology
  • Water-Electrolyte Imbalance / etiology

Substances

  • Mineralocorticoid Receptor Antagonists
  • Spironolactone
  • Aldosterone
  • Eplerenone