Chemoenzymatic dynamic kinetic resolution

Trends Biotechnol. 2004 Mar;22(3):130-5. doi: 10.1016/j.tibtech.2004.01.005.

Abstract

During the past decade a new concept has appeared in asymmetric catalysis involving the combination of a biocatalyst and a chemocatalyst in one 'pot' leading to efficient deracemization via dynamic kinetic resolution (DKR). Here, we outline the different strategies that have been developed for efficient chemoenzymatic DKR, in particular the powerful combination of an enzyme and a metal catalyst.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biotransformation
  • Burkholderia cepacia / enzymology
  • Catalysis
  • Chemistry, Organic / methods
  • Enzymes / chemistry*
  • Enzymes / metabolism*
  • Esterification
  • Fungal Proteins
  • Hydrogen / chemistry
  • Kinetics
  • Lipase / chemistry
  • Lipase / metabolism
  • Models, Chemical
  • Molecular Structure
  • Oxidation-Reduction
  • Palladium / chemistry
  • Ruthenium / chemistry
  • Stereoisomerism
  • Substrate Specificity

Substances

  • Enzymes
  • Fungal Proteins
  • Palladium
  • Ruthenium
  • Hydrogen
  • Lipase
  • lipase B, Candida antarctica