Aged skin: detection of alterations of major collagen types ratio by image processing of electron-optical data

Margaret Tzaphlidou; Michalis Zervakis

doi:10.1016/j.micron.2003.11.008

Aged skin: detection of alterations of major collagen types ratio by image processing of electron-optical data

Micron. 2004;35(3):221-5. doi: 10.1016/j.micron.2003.11.008.

Authors

Margaret Tzaphlidou¹, Michalis Zervakis

Affiliation

¹ Laboratory of Medical Physics, Medical School, University of Ioannina, P.O. Box 1186, Ioannina 45110, Greece. mtzaphli@cc.uoi.gr

PMID: 15036276
DOI: 10.1016/j.micron.2003.11.008

Abstract

Automated algorithms are developed in this paper based on digital signal processing to correlate electron-optical data from skin collagen fibrils with known sequence data. In particular, they detect alterations on the ratio of major collagen types in skin upon age.

MeSH terms

Algorithms
Animals
Automation
Collagen / analysis*
Female
Image Processing, Computer-Assisted / methods*
Microscopy, Electron
Models, Theoretical
Protein Isoforms / analysis*
Rats
Skin / chemistry
Skin / ultrastructure
Skin Aging / pathology*

Substances

Protein Isoforms
Collagen