Abstract
Several compounds possessing imidazo[4,5-b]pyridine and benzimidazole structure bearing substituents in position 2 were prepared in order to evaluate an anti-ulcer and gastroprotective activity in rat pylorus ligature, in comparison with omeprazole. Among sixteen compounds taken as representatives of the synthetised series only one (3d) showed a good activity by i.m. administration at 50 mg/kg, while by oral administration of 100 mg/kg a certain number was active and in some cases this activity was quite superior to that of omeprazole.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Ulcer Agents / chemical synthesis*
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Anti-Ulcer Agents / pharmacology
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / pharmacology
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Chemical Phenomena
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Chemistry
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Dogs
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology
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Male
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Omeprazole / pharmacology
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Pylorus / physiology
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Pyridines / chemical synthesis*
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Pyridines / pharmacology
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Rats
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Rats, Inbred Strains
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Stomach / drug effects*
Substances
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Anti-Ulcer Agents
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Benzimidazoles
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Imidazoles
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Pyridines
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Omeprazole