Thallium induces apoptosis in Jurkat cells

Ann N Y Acad Sci. 2003 Dec:1010:283-91. doi: 10.1196/annals.1299.049.

Abstract

Thallium induces swelling in mitochondria and apoptosis in Jurkat cells. Both the swelling and the apoptosis are inhibited by means of cyclosporine A (CsA), thus suggesting that these phenomena result from the opening of the membrane transition pore (MTP) in mitochondria. Therefore, apoptosis can be explained as due to the opening of the MTP in mitochondria.

MeSH terms

  • Apoptosis / drug effects*
  • Cell Survival / drug effects
  • Cyclosporine / pharmacology
  • Humans
  • Intracellular Membranes / drug effects
  • Intracellular Membranes / physiology
  • Jurkat Cells
  • Mitochondria / drug effects
  • Mitochondria / physiology
  • Mitochondrial Swelling / drug effects
  • Necrosis
  • Phosphates / pharmacology
  • Thallium / pharmacology*

Substances

  • Phosphates
  • Cyclosporine
  • Thallium