Inhibition of JNK by HGF/SF prevents apoptosis induced by TNF-alpha

Sylvie Reveneau; Réjane Paumelle; Julien Deheuninck; Catherine Leroy; Yvan De Launoit; Véronique Fafeur

doi:10.1196/annals.1299.016

Inhibition of JNK by HGF/SF prevents apoptosis induced by TNF-alpha

Ann N Y Acad Sci. 2003 Dec:1010:100-3. doi: 10.1196/annals.1299.016.

Authors

Sylvie Reveneau¹, Réjane Paumelle, Julien Deheuninck, Catherine Leroy, Yvan De Launoit, Véronique Fafeur

Affiliation

¹ Ecole Pratique des Hautes Etudes, Institut National de la Santé et de la Recherche Médicale U517, BP 87900, 21079 Dijon, France. Sylvie.Reveneau@u-bourgogne.fr

PMID: 15033702
DOI: 10.1196/annals.1299.016

Abstract

We investigated whether repression of JNK by hepatocyte growth factor/scatter factor (HGF/SF) in MDCK epithelial cells is linked to its ability to protect cells from apoptosis. To this purpose, cells were treated by TNF-alpha, a well-known inducer of JNK and of cell death, and the effects of HGF/SF were investigated under these conditions. We identified repression of JNK as a signaling target of HGF/SF for protection against TNF-alpha-induced cell death. This effect of HGF/SF occurs via the activation of the PI3K and MEK1 pathways.

MeSH terms

Animals
Apoptosis / drug effects
Apoptosis / physiology*
Cell Line
Cell Survival / drug effects
Chromones / pharmacology
Dogs
Enzyme Inhibitors / pharmacology
Hepatocyte Growth Factor / pharmacology*
JNK Mitogen-Activated Protein Kinases*
MAP Kinase Kinase 4
Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors*
Morpholines / pharmacology
Tumor Necrosis Factor-alpha / pharmacology*
Urothelium

Substances

Chromones
Enzyme Inhibitors
Morpholines
Tumor Necrosis Factor-alpha
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Hepatocyte Growth Factor
JNK Mitogen-Activated Protein Kinases
MAP Kinase Kinase 4
Mitogen-Activated Protein Kinase Kinases