Conversion of 7-deoxy-10-deacetylbaccatin-III into 6-alpha-hydroxy-7-deoxy-10-deacetylbaccatin-III by Nocardioides luteus

Biotechnol Appl Biochem. 2004 Apr;39(Pt 2):209-14. doi: 10.1042/BA20030093.

Abstract

6-alpha-Hydroxy-7-deoxy-10-deacetylbaccatin-III is an intermediate that is potentially useful for synthesis of analogues of paclitaxel. Screening of microbial strains identified an enzyme activity in Nocardioides luteus SC 13912 (A.T.C.C. 55426) which converted 7-deoxy-10-deacetylbaccatin-III into 6-hydroxy-7-deoxy-10-deacetylbaccatin-III with a maximum yield of 44%.

Publication types

  • Evaluation Study

MeSH terms

  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / metabolism
  • Bioreactors / microbiology*
  • Biotransformation
  • Hydrolysis
  • Nocardia / classification*
  • Nocardia / growth & development
  • Nocardia / metabolism*
  • Pilot Projects
  • Species Specificity
  • Taxoids / isolation & purification*
  • Taxoids / metabolism*

Substances

  • 6-alpha-hydroxy-7-deoxy-10-deacetylbaccatin-III
  • 7-deoxy-10-deacetylbaccatin-III
  • Antineoplastic Agents
  • Taxoids