Two new cytotoxic isoprenylated flavones, artoindonesianins U and V, from the heartwood of Artocarpus champeden

Yana M Syah; Sjamsul A Achmad; Emilio L Ghisalberti; Euis H Hakim; Didin Mujahidin

doi:10.1016/j.fitote.2003.11.005

Two new cytotoxic isoprenylated flavones, artoindonesianins U and V, from the heartwood of Artocarpus champeden

Fitoterapia. 2004 Mar;75(2):134-40. doi: 10.1016/j.fitote.2003.11.005.

Authors

Yana M Syah¹, Sjamsul A Achmad, Emilio L Ghisalberti, Euis H Hakim, Didin Mujahidin

Affiliation

¹ Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.

PMID: 15030917
DOI: 10.1016/j.fitote.2003.11.005

Abstract

Two new isoprenylated flavones, artoindonesianins U (1) and V (2), have been isolated from the heartwood of Artocarpus champeden together with three known isoprenylated flavonoids, 5'-hydroxycudraflavone A, cyclocommunin and artonin B. The structures of the new flavones were elucidated on the basis of spectroscopic evidence. Both compounds 1 and 2 showed strong cytotoxic activity against P-388 cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / administration & dosage
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology*
Antineoplastic Agents, Phytogenic / therapeutic use
Artocarpus*
Cell Line, Tumor / drug effects
Flavonoids / administration & dosage
Flavonoids / chemistry
Flavonoids / pharmacology*
Flavonoids / therapeutic use
Humans
Phytotherapy*
Plant Extracts / administration & dosage
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Plant Extracts / therapeutic use

Substances

Antineoplastic Agents, Phytogenic
Flavonoids
Plant Extracts
artoindonesianin U
artoindonesianin V