Doxorubicin prodrug on the basis of tert-butyl cephalosporanate sulfones

Grigory Veinberg; Irina Shestakova; Maxim Vorona; Iveta Kanepe; Ilona Domrachova; Edmunds Lukevics

doi:10.1016/j.bmcl.2003.11.071

Doxorubicin prodrug on the basis of tert-butyl cephalosporanate sulfones

Bioorg Med Chem Lett. 2004 Feb 23;14(4):1007-10. doi: 10.1016/j.bmcl.2003.11.071.

Authors

Grigory Veinberg¹, Irina Shestakova, Maxim Vorona, Iveta Kanepe, Ilona Domrachova, Edmunds Lukevics

Affiliation

¹ Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, Riga, LV 1006, Latvia. veinberg@osi.lv

PMID: 15013011
DOI: 10.1016/j.bmcl.2003.11.071

Abstract

Doxorubicin-cephalosporin prodrug adapted to the development of elastases for the liberation of parent drug was synthesized on the basis of cephalosporanate sulfone esters.

MeSH terms

Animals
Cell Line, Tumor
Cell Survival / drug effects
Cephalosporins / chemical synthesis*
Cephalosporins / pharmacology
Doxorubicin / chemical synthesis
Doxorubicin / pharmacology*
Drug Design
Esters / chemical synthesis*
Esters / pharmacology
Humans
Mice
Molecular Structure
Pancreatic Elastase / antagonists & inhibitors
Prodrugs / chemical synthesis
Prodrugs / pharmacology
Sulfones / chemical synthesis*
Sulfones / pharmacology

Substances

Cephalosporins
Esters
Prodrugs
Sulfones
Doxorubicin
Pancreatic Elastase