Haemodynamic crisis and reversible multiorgan failure caused by HIV post-exposure prophylaxis after needle-stick injury in a health care worker

T Feldt; M Oette; K Goebels; M Wenning; A Kroidl; D Häussinger

doi:10.1111/j.1468-1293.2004.00189.x

Haemodynamic crisis and reversible multiorgan failure caused by HIV post-exposure prophylaxis after needle-stick injury in a health care worker

HIV Med. 2004 Mar;5(2):125-7. doi: 10.1111/j.1468-1293.2004.00189.x.

Authors

T Feldt¹, M Oette, K Goebels, M Wenning, A Kroidl, D Häussinger

Affiliation

¹ Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany. Feldt@med.uni-duesseldorf.de

PMID: 15012653
DOI: 10.1111/j.1468-1293.2004.00189.x

Abstract

We report the case of a 59-year-old nurse from our HIV ward who developed a severe haemodynamic crisis with concomitant acute multiorgan failure after initiation of a post-exposure prophylaxis (PEP) with zidovudine/lamivudine (CombivirTM) and lopinavir/ritonavir (KaletraTM) after a needle-stick injury with an HIV-contaminated needle. Although serious and life-threatening adverse effects of post-exposure prophylaxis have been documented in several cases, this is the first report of a severe acute cardiovascular incident following PEP initiation.

Publication types

Case Reports

MeSH terms

Antiretroviral Therapy, Highly Active / adverse effects*
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / drug therapy*
Drug Interactions
Female
HIV Infections / prevention & control
Humans
Infectious Disease Transmission, Patient-to-Professional*
Middle Aged
Multiple Organ Failure / complications
Needlestick Injuries / complications*
Nurses
Occupational Exposure / adverse effects*