Highly diastereoselective synthesis of anti-gamma-N-benzylamino-beta-hydroxyphosphonates

Chem Commun (Camb). 2004 Mar 21:(6):672-3. doi: 10.1039/b316262a. Epub 2004 Feb 10.

Abstract

The reduction of gamma-N-benzylamino-beta-ketophosphonates derived from readily available amino acids can be carried out stereoselectively with Zn(BH(4))(2) at -78 degrees C to produce the anti-gamma-amino-beta-hydroxyphosphonates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzylamines / chemical synthesis*
  • Benzylamines / chemistry
  • Molecular Conformation
  • Organophosphorus Compounds / chemical synthesis*
  • Organophosphorus Compounds / chemistry
  • Stereoisomerism

Substances

  • Benzylamines
  • Organophosphorus Compounds