Evening melatonin and bright light administration induce additive phase shifts in dim light melatonin onset

J Pineal Res. 2004 Apr;36(3):192-4. doi: 10.1111/j.1600-079x.2004.00117.x.

Abstract

In healthy young men, administration of a single light pulse (5000 lux for 3 hr) or a single melatonin pill (5 mg) at 20:40 hr under controlled constant routine conditions of <10 lux, yielded a phase delay and a phase advance, respectively, in the circadian marker of dim light melatonin onset 24 hr later. Phase shifts after combining the two interventions were additive. Melatonin suppression is not necessary for a phase shift by light, and melatonin is not a 'weak' Zeitgeber relative to bright light when ambient lighting is strictly controlled.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Circadian Rhythm / physiology*
  • Cross-Over Studies
  • Humans
  • Light*
  • Male
  • Melatonin / blood*

Substances

  • Melatonin