Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XXII. Derivatives of 1-methoxy-5-bicyclo[2.2.2]-oct-5-one-2,3-dicarboximide

Jerzy Kossakowski; Monika Jarocka-Wierzba

Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XXII. Derivatives of 1-methoxy-5-bicyclo[2.2.2]-oct-5-one-2,3-dicarboximide

Acta Pol Pharm. 2003 Sep-Oct;60(5):367-74.

Authors

Jerzy Kossakowski¹, Monika Jarocka-Wierzba

Affiliation

¹ Department of Medical Chemistry, The Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland.

PMID: 15005420

Abstract

Continuing our studies with the design of new anxiolytics we have now synthesized a series of new compounds, derivatives of 1-methoxybicyclo[2.2.2]-oct-5-one-2,3-dicarboximide bearing a 4-aryl-1-piperazinylbutyl group attached to the imide nitrogen.

Publication types

Comparative Study

MeSH terms

Animals
Anti-Anxiety Agents / chemical synthesis*
Anti-Anxiety Agents / chemistry
Anti-Anxiety Agents / pharmacology
Bridged Bicyclo Compounds / chemical synthesis*
Bridged Bicyclo Compounds / chemistry
Bridged Bicyclo Compounds / pharmacology
Dose-Response Relationship, Drug
Imides / chemical synthesis*
Imides / chemistry
Imides / pharmacology
Injections, Intraperitoneal
Male
Motor Activity / drug effects
Rats
Rats, Wistar
Structure-Activity Relationship

Substances

1-methoxy-5-bicyclo(2.2.2)-oct-5-one-2,3-dicarboximide
Anti-Anxiety Agents
Bridged Bicyclo Compounds
Imides