Influence of L-arginine and vitamin C on the autonomic nervous system in chronic heart failure secondary to ischemic cardiomyopathy

Gianfranco Piccirillo; Quaglione Raffaele; Filippo Fimognari; Antonio Moisè; Malavasi Mario; Marco Lionetti; Camilla Naso; Silvia Di Carlo; Marialuce Nocco; Damiano Magrì

doi:10.1016/j.amjcard.2003.11.043

Influence of L-arginine and vitamin C on the autonomic nervous system in chronic heart failure secondary to ischemic cardiomyopathy

Am J Cardiol. 2004 Mar 1;93(5):650-4. doi: 10.1016/j.amjcard.2003.11.043.

Authors

Gianfranco Piccirillo¹, Quaglione Raffaele, Filippo Fimognari, Antonio Moisè, Malavasi Mario, Marco Lionetti, Camilla Naso, Silvia Di Carlo, Marialuce Nocco, Damiano Magrì

Affiliation

¹ Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università La Sapienza, Rome, Italy. gianfranco.piccirillo@uniroma1.it

PMID: 14996603
DOI: 10.1016/j.amjcard.2003.11.043

Abstract

In this study, we used spectral analysis to assess changes in respiratory recording variability during infusion of L-arginine and vitamin C, individually or together, in patients with chronic heart failure. We found that healthy subjects have a substantial ability to modulate sympathetic-mediated peripheral vascular resistance through endothelial synthesis of nitric oxide. Patients with chronic heart failure lose this ability.

Publication types

Clinical Trial
Randomized Controlled Trial

MeSH terms

Algorithms
Antioxidants / pharmacology*
Arginine / pharmacology*
Ascorbic Acid / pharmacology*
Autonomic Nervous System / drug effects*
Cardiomyopathy, Dilated / etiology
Cardiomyopathy, Dilated / physiopathology*
Cross-Over Studies
Female
Humans
Male
Middle Aged
Myocardial Ischemia / complications
Respiration / drug effects*
Signal Processing, Computer-Assisted
Single-Blind Method
Vascular Resistance / drug effects

Substances

Antioxidants
Arginine
Ascorbic Acid