Motor protein with nonequilibrium potential: Its thermodynamics and efficiency

Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Jan;69(1 Pt 1):012901. doi: 10.1103/PhysRevE.69.012901. Epub 2004 Jan 29.

Abstract

A nonequilibrium potential function is introduced for a motor protein modeled by a rectified Brownian motion. This result provides a concrete case for a class of nonequilibrium systems in steady state with dissipation which possess a potential function. The potential micro is a natural generalization of the chemical potential for isothermal chemical species and micro=const if and only if the system is in an equilibrium. The steady-state flux J proportional, variant - nabla micro, and the total heat dissipation h(d) equals a surface integral integral microJ.dS, representing the energy input. In terms of micro and h(d) the thermodynamic energy conservation in the mesoscopic stochastic system can be rigorously established and various types of motor efficiency are elucidated.

MeSH terms

  • Adenosine Diphosphate / chemistry
  • Adenosine Triphosphate / chemistry*
  • Adenosine Triphosphate / metabolism*
  • Computer Simulation
  • Energy Transfer / physiology*
  • Models, Biological*
  • Models, Chemical
  • Molecular Motor Proteins / chemistry*
  • Molecular Motor Proteins / physiology*
  • Motion
  • Proteins / chemistry*
  • Proteins / physiology*
  • Thermodynamics

Substances

  • Molecular Motor Proteins
  • Proteins
  • Adenosine Diphosphate
  • Adenosine Triphosphate