Abstract
Three new compounds: begonanline (1). nantoamide (2). and methyl (S)-glycerate (3). as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray crystallography. Among them, cucurbitacin B (4). dihydrocucurbitacin B (5). cucurbitacin E (6). dihydrocucurbitacin E (7). cucurbitacin I (8). and (-)-auranamide (9). showed cytotoxicity against four human cancer cell lines. 3beta,22alpha-Dihydroxyolean-12-en-29-oic acid (10), indole-3-carboxylic acid (11), 5,7-dihydroxychromone (12), and (-)-catechin (13) demonstrated significant activity against HIV replication in H9 lymphocyte cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Begoniaceae / chemistry*
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Benzamides / chemistry
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Benzamides / isolation & purification*
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Benzamides / pharmacology
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Carbolines / chemistry
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Carbolines / isolation & purification*
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Carbolines / pharmacology
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China
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Crystallography, X-Ray
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Glyceric Acids / chemistry
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Glyceric Acids / isolation & purification*
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Glyceric Acids / pharmacology
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Humans
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Lymphocytes / drug effects
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Rhizome / chemistry
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
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Tumor Cells, Cultured
Substances
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Anti-HIV Agents
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Antineoplastic Agents, Phytogenic
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Benzamides
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Carbolines
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Glyceric Acids
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Triterpenes
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begonanline
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methyl (S)-glycerate
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nantoamide
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cucurbitacin B
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cucurbitacin E