Staphylococcus aureus isolates with reduced susceptibility to glycopeptides belong to accessory gene regulator group I or II

Antimicrob Agents Chemother. 2004 Mar;48(3):1024-7. doi: 10.1128/AAC.48.3.1024-1027.2004.

Abstract

We used multiplex PCR to determine the agr group membership of 18 European glycopeptide heterointermediate and intermediate-resistant Staphylococcus aureus strains. Of the 15 agr group I strains, 13 were resistant and 2 were susceptible to methicillin. The remaining three strains, like the United States and Japanese control strains, belonged to agr group II.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Electrophoresis, Polyacrylamide Gel
  • Gene Expression Regulation, Bacterial / genetics*
  • Genes, Bacterial / genetics*
  • Glycopeptides / pharmacology*
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Reverse Transcriptase Polymerase Chain Reaction
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics*

Substances

  • Anti-Bacterial Agents
  • Glycopeptides