In vitro activities of moxifloxacin against 900 aerobic and anaerobic surgical isolates from patients with intra-abdominal and diabetic foot infections

Charles E Edmiston; Candace J Krepel; Gary R Seabrook; Lewis R Somberg; Atilla Nakeeb; Robert A Cambria; Jonathan B Towne

doi:10.1128/AAC.48.3.1012-1016.2004

In vitro activities of moxifloxacin against 900 aerobic and anaerobic surgical isolates from patients with intra-abdominal and diabetic foot infections

Antimicrob Agents Chemother. 2004 Mar;48(3):1012-6. doi: 10.1128/AAC.48.3.1012-1016.2004.

Authors

Charles E Edmiston¹, Candace J Krepel, Gary R Seabrook, Lewis R Somberg, Atilla Nakeeb, Robert A Cambria, Jonathan B Towne

Affiliation

¹ Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. edmiston@mcw.edu

Abstract

The in vitro activities of moxifloxacin, ciprofloxacin, levofloxacin, gatifloxacin, imipenem, piperacillin-tazobactam, clindamycin, and metronidazole against 900 surgical isolates were determined using NCCLS testing methods. Moxifloxacin exhibited good to excellent antimicrobial activity against most aerobic (90.8%) and anaerobic (97.1%) microorganisms, suggesting that it may be effective for the treatment of polymicrobial surgical infections.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abdomen / microbiology
Anti-Infective Agents / pharmacology*
Aza Compounds / pharmacology*
Bacteria, Aerobic / drug effects*
Bacteria, Anaerobic / drug effects*
Bacterial Infections / microbiology*
Diabetic Foot / microbiology*
Diabetic Foot / surgery
Fluoroquinolones
Humans
Microbial Sensitivity Tests
Moxifloxacin
Quinolines / pharmacology*

Substances

Anti-Infective Agents
Aza Compounds
Fluoroquinolones
Quinolines
Moxifloxacin