Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond

J Neurovirol. 2004:10 Suppl 1:97-101. doi: 10.1080/753312759.

Abstract

Dementia can occur as a debilitating consequence of human immunodeficiency virus-1 (HIV-1) infection. The neuropathology incited by HIV infection involves activation of chemokine receptors, inflammatory factors, and N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity, all of which can activate several downstream mechanisms. This article discusses recently identified pathways to neuronal damage triggered by HIV-1 and efforts aimed at development of applicable therapeutic intervention.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • AIDS Dementia Complex / immunology
  • AIDS Dementia Complex / pathology*
  • Apoptosis
  • HIV-1*
  • Humans
  • Neurons / pathology
  • Neurons / virology*
  • Neurotoxins / immunology
  • Receptors, Chemokine / immunology*
  • Signal Transduction / immunology*

Substances

  • Neurotoxins
  • Receptors, Chemokine