Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[g]quinoxaline-5,10-diones

Heesoon Lee; Sungmoon Cho; Kwon Namgoong; Jae-Kyung Jung; Jungsook Cho; Sung-Il Yang

doi:10.1016/j.bmcl.2003.12.046

Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[g]quinoxaline-5,10-diones

Bioorg Med Chem Lett. 2004 Mar 8;14(5):1235-7. doi: 10.1016/j.bmcl.2003.12.046.

Authors

Heesoon Lee¹, Sungmoon Cho, Kwon Namgoong, Jae-Kyung Jung, Jungsook Cho, Sung-Il Yang

Affiliation

¹ College of Pharmacy, Chungbuk National University, Cheongju 361-763, South Korea. medchem@chungbuk.ac.kr

PMID: 14980672
DOI: 10.1016/j.bmcl.2003.12.046

Abstract

A series of benzo[g]quinoxaline-5,10-dione derivatives carrying a 7-dialkylaminomethyl substituent was synthesized and their in vitro cytotoxic activities were evaluated against four human cancer cell lines (HCT-15, SK-OV-3, MD-MB-468 and T-47D). The most active compound 9d showed cytotoxic activity comparable to that of doxorubicin against HCT-15 cancer cell line.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Drug Evaluation, Preclinical / methods
Humans
Quinoxalines / chemical synthesis*
Quinoxalines / pharmacology*

Substances

Quinoxalines