Diaryl naphthyl methanes a novel class of anti-implantation agents

Neeta Srivastava; Sangita; S Ray; M M Singh; Anila Dwivedi; Atul Kumar

doi:10.1016/j.bmc.2003.12.015

Diaryl naphthyl methanes a novel class of anti-implantation agents

Bioorg Med Chem. 2004 Mar 1;12(5):1011-21. doi: 10.1016/j.bmc.2003.12.015.

Authors

Neeta Srivastava¹, Sangita, S Ray, M M Singh, Anila Dwivedi, Atul Kumar

Affiliation

¹ Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow-226 001 (UP), India.

PMID: 14980614
DOI: 10.1016/j.bmc.2003.12.015

Abstract

Diaryl naphthyl methanes and the corresponding 1, 2, 3, 4- and 5, 6, 7, 8-tetrahydro naphthyl methane derivatives have been synthesized as novel estrogen receptor binding ligands. The secondary and tertiary amino alkoxy derivatives of diaryl naphthyl and tetrahydro naphthyl methane interact with the estrogen receptor to elicit promising estrogenic, antiestrogenic and implantation inhibition activities in rats. The most active compounds in this series are 7, 9 and 20, cent percent active in preventing implantation in rats at 2.5 mgkg(-1) dose.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dose-Response Relationship, Drug
Embryo Implantation / drug effects*
Estrogen Antagonists / chemical synthesis*
Estrogen Antagonists / pharmacology
Female
Ligands
Models, Molecular
Naphthols / chemical synthesis*
Naphthols / pharmacology*
Organ Size / drug effects
Rats
Receptors, Estrogen / agonists
Receptors, Estrogen / antagonists & inhibitors
Structure-Activity Relationship
Uterus / drug effects

Substances

Estrogen Antagonists
Ligands
Naphthols
Receptors, Estrogen