Inhibitory effect of antiserum to surface antigen P50 of Babesia gibsoni on growth of parasites in severe combined immunodeficiency mice given canine red blood cells

Infect Immun. 2004 Mar;72(3):1795-8. doi: 10.1128/IAI.72.3.1795-1798.2004.

Abstract

The inhibitory effect of an antiserum to surface protein P50 of Babesia gibsoni on the growth of the parasite was determined with severe combined immunodeficiency mice given canine red blood cells. The antiserum to the recombinant P50 protein significantly inhibited the parasite growth, indicating that P50 might be a useful vaccine candidate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Protozoan / administration & dosage*
  • Antigens, Protozoan / immunology*
  • Antigens, Surface
  • Babesia / growth & development
  • Babesia / immunology*
  • Babesia / pathogenicity
  • Babesiosis / immunology
  • Babesiosis / parasitology
  • Babesiosis / prevention & control
  • Babesiosis / veterinary
  • Dog Diseases / immunology
  • Dog Diseases / parasitology
  • Dog Diseases / prevention & control
  • Dogs
  • Erythrocyte Transfusion
  • Erythrocytes / parasitology
  • Female
  • Mice
  • Mice, SCID
  • Protozoan Vaccines / isolation & purification
  • Recombinant Proteins / immunology
  • Vaccines, Synthetic / isolation & purification

Substances

  • Antibodies, Protozoan
  • Antigens, Protozoan
  • Antigens, Surface
  • P50 protein, Babesia gibsoni
  • Protozoan Vaccines
  • Recombinant Proteins
  • Vaccines, Synthetic