Identification of 5-fluoro-5-deoxy-D-ribose-1-phosphate as an intermediate in fluorometabolite biosynthesis in Streptomyces cattleya

Steven L Cobb; Hai Deng; John T G Hamilton; Ryan P McGlinchey; David O'Hagan

doi:10.1039/b400754a

Identification of 5-fluoro-5-deoxy-D-ribose-1-phosphate as an intermediate in fluorometabolite biosynthesis in Streptomyces cattleya

Chem Commun (Camb). 2004 Mar 7:(5):592-3. doi: 10.1039/b400754a. Epub 2004 Feb 3.

Authors

Steven L Cobb¹, Hai Deng, John T G Hamilton, Ryan P McGlinchey, David O'Hagan

Affiliation

¹ School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, St. Andrews, Fife, UK KY16 9ST.

PMID: 14973623
DOI: 10.1039/b400754a

Abstract

5'-Fluoro-5'-deoxy-D-ribose-1-phosphate (FDRP) is identified as a biosynthetic intermediate during fluorometabolite biosynthesis in Streptomyces cattleya.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, High Pressure Liquid
Chromatography, Ion Exchange
Fluorides / metabolism*
Magnetic Resonance Spectroscopy
Nucleosides / metabolism
Phosphorylases / metabolism
Ribosemonophosphates / chemistry
Ribosemonophosphates / metabolism*
Spectrophotometry, Ultraviolet
Streptomyces / enzymology
Streptomyces / metabolism*

Substances

5-fluoro-5-deoxy-D-ribose-1-phosphate
Nucleosides
Ribosemonophosphates
Phosphorylases
Fluorides