Restriction fragments length polymorphism in the NAT1 gene of Europeans in West Siberia

M V Nikishina; A G Akishev; V A Vavilin; S I Makarova; S Kh Degtyarev; V V Lyakhovich

doi:10.1023/b:bebm.0000017099.51849.93

Restriction fragments length polymorphism in the NAT1 gene of Europeans in West Siberia

Bull Exp Biol Med. 2003 Nov;136(5):482-4. doi: 10.1023/b:bebm.0000017099.51849.93.

Authors

M V Nikishina¹, A G Akishev, V A Vavilin, S I Makarova, S Kh Degtyarev, V V Lyakhovich

Affiliation

¹ Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.

PMID: 14968166
DOI: 10.1023/b:bebm.0000017099.51849.93

Abstract

Restriction fragment length polymorphism in the NAT1 gene was assayed to reveal 7 mutations (97C>T; 190C>T; 350,351G>C; 402T>C; 752A>T; D(1105); D(1025)) in 74 Europeans from West Siberia. New methods for detecting mutations 350,351G>C, 402T>C, 752A>T, D(1105), and D(1025) were proposed.

MeSH terms

Alleles
Arylamine N-Acetyltransferase / genetics*
DNA Restriction Enzymes / metabolism
Europe / ethnology
Gene Frequency
Heterozygote
Humans
Isoenzymes
Mutation
Polymorphism, Restriction Fragment Length*
Siberia
White People / genetics*

Substances

Isoenzymes
Arylamine N-Acetyltransferase
N-acetyltransferase 1
DNA Restriction Enzymes