Teething with IKKalpha to make notches

Mol Cell. 2004 Feb 13;13(3):301-2. doi: 10.1016/s1097-2765(04)00058-9.

Abstract

Sharpe and colleagues unveil a crucial role for NF-kappaB activity in tooth development, and show that IKKalpha functions both within and independently from the NF-kappaB pathway during molar and incisor morphogenesis, respectively (in the February issue of Developmental Cell).

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Developmental / genetics
  • Humans
  • I-kappa B Kinase
  • Organogenesis / genetics
  • Protein Serine-Threonine Kinases / genetics*
  • Protein Serine-Threonine Kinases / metabolism
  • Receptor, Notch1
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / metabolism
  • Signal Transduction / genetics
  • Tooth / cytology
  • Tooth / embryology*
  • Tooth / metabolism
  • Tooth Abnormalities / genetics*
  • Tooth Abnormalities / metabolism
  • Transcription Factors*

Substances

  • NOTCH1 protein, human
  • Receptor, Notch1
  • Receptors, Cell Surface
  • Transcription Factors
  • Protein Serine-Threonine Kinases
  • CHUK protein, human
  • I-kappa B Kinase
  • IKBKB protein, human
  • IKBKE protein, human