Abstract
Sharpe and colleagues unveil a crucial role for NF-kappaB activity in tooth development, and show that IKKalpha functions both within and independently from the NF-kappaB pathway during molar and incisor morphogenesis, respectively (in the February issue of Developmental Cell).
MeSH terms
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Animals
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Gene Expression Regulation, Developmental / genetics
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Humans
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I-kappa B Kinase
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Organogenesis / genetics
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Protein Serine-Threonine Kinases / genetics*
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Protein Serine-Threonine Kinases / metabolism
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Receptor, Notch1
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Receptors, Cell Surface / genetics*
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Receptors, Cell Surface / metabolism
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Signal Transduction / genetics
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Tooth / cytology
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Tooth / embryology*
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Tooth / metabolism
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Tooth Abnormalities / genetics*
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Tooth Abnormalities / metabolism
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Transcription Factors*
Substances
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NOTCH1 protein, human
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Receptor, Notch1
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Receptors, Cell Surface
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Transcription Factors
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Protein Serine-Threonine Kinases
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CHUK protein, human
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I-kappa B Kinase
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IKBKB protein, human
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IKBKE protein, human