HDL action on the vascular wall: is the answer NO?

J Clin Invest. 2004 Feb;113(4):509-13. doi: 10.1172/JCI21072.

Abstract

Circulating levels of HDL cholesterol are inversely related to the risk of atherosclerosis, and therapeutic increases in HDL reduce the incidence of cardiovascular events. A new study shows that HDL-associated lysophospholipids stimulate the production of the potent antiatherogenic signaling molecule NO by the vascular endothelium.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Arteriosclerosis / metabolism
  • Cholesterol, HDL / metabolism*
  • Endothelium, Vascular / metabolism*
  • Humans
  • Nitric Oxide / metabolism*
  • Nitric Oxide Synthase / metabolism
  • Nitric Oxide Synthase Type III
  • Signal Transduction / physiology

Substances

  • Cholesterol, HDL
  • Nitric Oxide
  • NOS3 protein, human
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type III