Improvement of clinical and MRI findings in a boy with adrenoleukodystrophy by dietary erucic acid therapy

K Maeda; Y Suzuki; S Yajima; J Asano; S Yamaguchi; N Matsumoto; J Borel; H W Moser; T Orii

doi:10.1016/s0387-7604(12)80350-0

Improvement of clinical and MRI findings in a boy with adrenoleukodystrophy by dietary erucic acid therapy

Brain Dev. 1992 Nov;14(6):409-12. doi: 10.1016/s0387-7604(12)80350-0.

Authors

K Maeda¹, Y Suzuki, S Yajima, J Asano, S Yamaguchi, N Matsumoto, J Borel, H W Moser, T Orii

Affiliation

¹ Department of Pediatrics, Shizuoka Saiseikai General Hospital, Japan.

PMID: 1492654
DOI: 10.1016/s0387-7604(12)80350-0

Abstract

A 5-year-old boy with adrenoleukodystrophy, with clinical symptoms of visual, mental and motor disturbances which progressed rapidly, was treated with Lorenzo's oil consisting 1 volume of glyceryl trierucate and 4 volumes of glyceryl trioleate. Five months after initiation of this therapy, ability to swallow was enhanced and T2-weighted magnetic resonance imaging of the brain revealed regression of high intensity area of the parieto-occipital white matter.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adrenoleukodystrophy / diet therapy*
Adrenoleukodystrophy / pathology
Adrenoleukodystrophy / physiopathology
Brain / pathology
Child, Preschool
Dietary Fats, Unsaturated / therapeutic use*
Drug Combinations
Erucic Acids / therapeutic use*
Humans
Magnetic Resonance Imaging
Male
Triolein / therapeutic use*

Substances

Dietary Fats, Unsaturated
Drug Combinations
Erucic Acids
Lorenzo's oil
Triolein