This study illustrates the possible topical therapy of OLP with cyclosporine A under bioadhesive gel formula. The treatment was carried out on 6 patients for 8 weeks in much lower (48 mg/day) than those used by other authors. The novelty of this study lies in the use of a bioadhesive formula with carbosymethylcellulose which allows CsA to remain on oral mucosa for about two hours. The remarkable results have shown a reduction ranging from 50 to 80% of oral lesions, thus proposing its specific use in all the forms resisting usual therapy.