Abstract
Atri-hydrazidophosphine oxide (THP) ligand was synthesized and used to complex 99mTc in high yield (> 95%) by Sn(II) reduction of 99mTcO4-. 99mTc-THP has excellent stability in both 0.9% acqueous NaCl at neutral pH and in human serum at 37 degrees C. Biodistribution studies indicate minimal organ specificity and no significant in vivo release of 99mTcO4-. The ease of 99mTc complexation with THP and the high stability of 99mTc-THP suggests that this ligand may be used as a basis for the development of new imaging agents.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Humans
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Organophosphorus Compounds / blood
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Organophosphorus Compounds / chemical synthesis*
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Organophosphorus Compounds / pharmacokinetics
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Organotechnetium Compounds / blood
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Organotechnetium Compounds / chemical synthesis*
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Organotechnetium Compounds / pharmacokinetics
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Phosphines*
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Rats
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Rats, Sprague-Dawley
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Tissue Distribution
Substances
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Organophosphorus Compounds
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Organotechnetium Compounds
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Phosphines
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technetium Tc 99m trihydrazidophosphine oxide