Abstract
Human ST2 cDNA, a homologue of murine ST2 that is only expressed in growth-stimulated BALB/c-3T3 cells and a member of the primary response gene family induced by growth factors, was isolated from the cDNA library of an activated human helper T cell line, 5C10. Human ST2 has 67.6% identity in a 327 amino acid overlap to murine ST2. Furthermore, as in the case of murine ST2, human ST2 encodes a protein remarkably similar in sequence to the extracellular portion of human interleukin 1 receptor, both types 1 and 2. The expression of ST2 in human lymphocytes could trigger further investigations into its physiological role in humans.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3 Cells
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Amino Acid Sequence
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Animals
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Base Sequence
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Cloning, Molecular
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DNA / genetics*
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Genomic Library
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Granulocytes / physiology
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Humans
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Interleukin-1 Receptor-Like 1 Protein
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Membrane Proteins*
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Mice
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Molecular Sequence Data
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Polymerase Chain Reaction / methods
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Proteins / genetics*
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Receptors, Cell Surface
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Receptors, Interleukin
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Restriction Mapping
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Sequence Homology, Amino Acid
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Software
Substances
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IL1RL1 protein, human
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Il1rl1 protein, mouse
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Interleukin-1 Receptor-Like 1 Protein
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Membrane Proteins
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Proteins
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Receptors, Cell Surface
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Receptors, Interleukin
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DNA
Associated data
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GENBANK/D12763
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GENBANK/D12764
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GENBANK/M91429
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GENBANK/M91430
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GENBANK/M93297
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GENBANK/M93298
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GENBANK/M93299
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GENBANK/M93300
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GENBANK/M93301
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GENBANK/S53047
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GENBANK/S55205