Nucleotide sequence of a complementary DNA for human ST2

Biochim Biophys Acta. 1992 Dec 29;1171(2):215-8. doi: 10.1016/0167-4781(92)90125-j.

Abstract

Human ST2 cDNA, a homologue of murine ST2 that is only expressed in growth-stimulated BALB/c-3T3 cells and a member of the primary response gene family induced by growth factors, was isolated from the cDNA library of an activated human helper T cell line, 5C10. Human ST2 has 67.6% identity in a 327 amino acid overlap to murine ST2. Furthermore, as in the case of murine ST2, human ST2 encodes a protein remarkably similar in sequence to the extracellular portion of human interleukin 1 receptor, both types 1 and 2. The expression of ST2 in human lymphocytes could trigger further investigations into its physiological role in humans.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA / genetics*
  • Genomic Library
  • Granulocytes / physiology
  • Humans
  • Interleukin-1 Receptor-Like 1 Protein
  • Membrane Proteins*
  • Mice
  • Molecular Sequence Data
  • Polymerase Chain Reaction / methods
  • Proteins / genetics*
  • Receptors, Cell Surface
  • Receptors, Interleukin
  • Restriction Mapping
  • Sequence Homology, Amino Acid
  • Software

Substances

  • IL1RL1 protein, human
  • Il1rl1 protein, mouse
  • Interleukin-1 Receptor-Like 1 Protein
  • Membrane Proteins
  • Proteins
  • Receptors, Cell Surface
  • Receptors, Interleukin
  • DNA

Associated data

  • GENBANK/D12763
  • GENBANK/D12764
  • GENBANK/M91429
  • GENBANK/M91430
  • GENBANK/M93297
  • GENBANK/M93298
  • GENBANK/M93299
  • GENBANK/M93300
  • GENBANK/M93301
  • GENBANK/S53047
  • GENBANK/S55205