Omeprazole-like compounds on histamine-stimulated acid and peptic secretions in conscious dog and cat

Boll Soc Ital Biol Sper. 1992 Jul;68(7):429-36.

Abstract

A newly synthetized aniline derivative series has been tested on histamine-stimulated gastric acid secretion in conscious cats and dogs and compared to the proton pump inhibitors omeprazole and NC 1300. The compounds markedly and long-lastingly inhibited acid output with a potency lower than omeprazole but very close to the reference compound NC 1300. The results show that the introduction of a nitrogen atom, irrespective of the position in the benzimidazole ring does not seem to influence the gastric antisecretory activity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Animals
  • Benzimidazoles / pharmacology*
  • Cats
  • Consciousness
  • Depression, Chemical
  • Dogs
  • Dose-Response Relationship, Drug
  • Drug Administration Routes
  • Duodenum / drug effects*
  • Duodenum / metabolism
  • Gastric Acid / metabolism*
  • Gastric Mucosa / drug effects*
  • Gastric Mucosa / metabolism
  • Histamine / pharmacology
  • Molecular Structure
  • Omeprazole / pharmacology*
  • Pepsin A / metabolism*
  • Secretory Rate / drug effects
  • Structure-Activity Relationship

Substances

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Benzimidazoles
  • 2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole
  • Histamine
  • Pepsin A
  • Omeprazole