Disclosing new inhibitors by finding similarities in three-dimensional active-site architectures of polynuclear zinc phospholipases and aminopeptidases

Angew Chem Int Ed Engl. 2004 Feb 6;43(7):862-5. doi: 10.1002/anie.200352241.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminopeptidases / antagonists & inhibitors
  • Aminopeptidases / chemistry*
  • Aminopeptidases / metabolism
  • Binding Sites
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Inhibitory Concentration 50
  • Kinetics
  • Metalloendopeptidases / chemistry
  • Metalloendopeptidases / metabolism
  • Models, Molecular
  • Phospholipases / antagonists & inhibitors
  • Phospholipases / chemistry*
  • Phospholipases / metabolism
  • Protein Conformation
  • Substrate Specificity
  • Zinc / chemistry*

Substances

  • Enzyme Inhibitors
  • Phospholipases
  • Aminopeptidases
  • Metalloendopeptidases
  • Zinc